Research implies that legislation of COX-2 appearance is an integral part of colorectal carcinogenesis

Research implies that legislation of COX-2 appearance is an integral part of colorectal carcinogenesis. cm, the positive rates of HER-2 and COX-2 expression were 81.48% (308/378) and 57.94% (219/378), respectively. In sufferers with serosal invasion, the positive COX-2 and HER-2 appearance rates had Rabbit Polyclonal to FA7 (L chain, Cleaved-Arg212) been 80.53% (612/760) and 49.21% (374/760), respectively. In sufferers with lymph node metastasis, CCG-203971 the positive appearance rates had been 85.04% (506/595) and 54.62% (325/595), respectively, as well as the positive appearance prices differed significantly between sufferers with lymph node metastasis and the ones without ( 0.05). In sufferers with Dukes D and C colorectal cancers, the positive COX-2 and HER-2 appearance rates had been 82.80% (443/535) and 57.94% (310/535), respectively. In sufferers with badly differentiated colorectal cancers, the positive appearance rates had been 74.49% (210/282) and 52.84% (149/282), ( 0 respectively.05). In sufferers with faraway metastasis, the positive appearance rates had been 82.27% (116/141) and 53.90% (76/141), respectively ( 0.05). These findings claim that HER-2 and COX-2 possess synergistic results in colorectal cancers. HER-2 and COX-2 appearance acquired no significant relationship with sex, age group, or tumor area. Bottom line: COX-2 and HER-2 are essential markers for invasion and metastasis of colorectal cancers, plus they act to modify the invasion and metastasis of colorectal cancers jointly. test. Survival analysis was conducted using the Kaplan-Meier method. 0.05 was considered statistically significant. RESULTS COX-2 expression in colorectal malignancy COX-2-positive cells showed brownish yellow granules in the cytoplasm (Physique ?(Figure1A).1A). The positive rate of COX-2 expression was 77.97% (800/1026) in all the specimens. In patients with a tumor size 5 cm, the positive rate of COX-2 expression was 81.48% (308/378). In patients with serosal invasion, the positive expression rate was 80.53% (612/760). In patients with Dukes C and D colorectal malignancy, the positive expression rate was 82.80% (443/535). In patients with lymph node metastasis, the positive expression rate was 85.04% (506/595), and the positive expression rate differed significantly between patients with lymph node metastasis and those without (2 = 41.213; 0.05). High COX-2 protein expression was significantly correlated with tumor size, infiltration depth, Dukes stage, tumor differentiation, distant metastasis, and lymph node metastasis ( 0.05), but not with sex, age, or tumor location (Table ?(Table11). Table 1 Relationship between COX-2/HER-2 expression and clinicopathologic factors (%) valuePositiveNegativevalue 0.05). High HER-2 protein expression was significantly correlated with tumor size, invasion depth, Dukes stage, tumor differentiation, distant metastasis, and lymph node metastasis ( 0.05), but not with sex, age, or tumor location (Table ?(Table11). Correlation between COX-2 and HER-2 expression in colorectal malignancy Of 800 COX-2 positive specimens, 350 were positive for HER-2 and 450 were unfavorable. Of 226 COX-2 unfavorable specimens, 124 were positive for HER-2 and 102 were negative. There was a significant positive correlation between COX-2 and HER-2 expression in colorectal malignancy (2 = 8.762; 0.05) (Table ?(Table22). Table 2 Relationship between COX-2 and HER-2 expression valuePositiveNegative 0.05). Open in a separate window Physique 2 Survival curves for patients with colorectal malignancy. A: Patients CCG-203971 with positive and negative COX-2 expression; B: Patients with positive and negative HER-2 expression. Open in a separate window Physique 3 Survival curves of colorectal malignancy patients positive for both COX-2 and HER-2, positive for either of them, and unfavorable for both. Compared with patients positive for both markers, patients unfavorable for both experienced better survival. Conversation According to the results of this CCG-203971 study, the positive rate of COX-2 expression in colorectal malignancy is usually 77.97%, significantly higher than in normal colorectal tissues. COX-2 expression was significantly associated with lymph node metastasis[4]. This may be because COX-2 CCG-203971 can: (1) increase the production of prostaglandins and inhibit the bodys immune response; (2) inhibit tumor cell apoptosis and promote cell proliferation; (3) regulate cell cycle progression; (4) promote tumor angiogenesis; (5) increase the expression of matrix metalloproteinases in tumor cells; and (6) induce activation of precursors of carcinogenic substances. As high COX-2 expression exists in precancerous lesions and carcinoma and is significantly higher than in the normal tissue, it is generally believed that.